Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection
Fig 6
Graphical summary of the proportions of simulations where ascension occurred and role of load (A), peristalsis (B), and both (C). (A) Simulations analysing the impact of infectious load (the count of initial bacteria) on the the chances of ascension. (B) The time (in minutes) prior to the onset of peristaltic contractions in the cervico-fundal direction and chances of ascension. (C) The relationship between infectious load, timing of infection with respect to peristaltic contractions, and the chances of ascension. Each figure shows the proportion of simulations from the model where the infection ascended (proportion of representations from 252, 500 simulations) on the y axis, where the x axis represents the factor being modified (A. infectious load, B. peristalsis, C. peristalsis and grouped by infectious load). These are simulated over a range of infectious loads (10 simulations at each value of infectious load from 1 to 10001 in steps of 100. The blue lines represent a loess regression against the proportion of simulations resulting in ascension, and the shaded regions are 95% confidence intervals of the regression. Dots represent simulations at a particular parameter value.