The evolutionary history of topological variations in the CPA/AT transporters
Fig 5
Broken-Reentrant transporter transitions by duplication of repeat unit.
(a) Sequence and topology alignment between Na_H_Exchanger_1 (CPA-broken fold-type) and DUF819 (CPA-reentrant fold-type). All the transmembrane helices are numbered sequentially and the reentrant helix is denoted as RH (b) Structure superposition of broken and reentrant transporter. The extra scaffold helix and the broken-reentrant transition are highlighted in bright colors. (c) A zoomed-in figure of broken (pink) and reentrant helix (yellow and blue) is shown. The glycines are shown in stick representation. (d) The aligned positions of the broken and reentrant N-core helix are represented as sequence motifs (e) Cartoon representation showing the events of duplication and mutation in reentrant transporters leading to the transition of broken-reentrant transporters.