Designing microbial communities to maximize the thermodynamic driving force for the production of chemicals
Fig 6
Excerpt of selected central reactions of the MDF-optimal single-species and community solution for kdo8p synthesis.
Black arrows indicate active reactions, dashed arrows indicate a sequence of active reactions, and the blue triangles indicate increased or decreased metabolite concentrations of a strain in the community relative to the other strain. The shown ΔrG′ and ΔrG′0 values have all unit kJ/mol. The ΔrG′ values are taken from the specific MDF-optimal solution delivered by ASTHERISC. The red ΔrG′ values indicate thermodynamic bottlenecks, i.e., reactions whose ΔrG′ is fixed under the optimal MDF (and corresponds to the negative value of the OptMDF) All black ΔrG′ values are variable under the given OptMDF. All reaction and metabolite identifiers are based on the definitions in the BiGG database [49].