Optimizing mitochondrial maintenance in extended neuronal projections
Fig 8
Effect of mitophagy, at fixed production rate kp.
(a) The total number of mitochondria in the domain (yellow) and the number of stationary mitochondria (blue) are plotted as a function of the mitophagy threshold, for both the CoG model (solid lines) and the SS model (dashed lines). Mitochondria quantities are normalized by the steady-state number of mitochondria in the absence of mitophagy. (b) Mitochondrial health for the CoG model, averaged over all demand sites, plotted as a function of mitophagy threshold and number of stopping events Ns. (c) Health at most distal demand site, for the CoG model. (d-e) Analogous plots of average health and distal site health for the SS model. All plots assume mitochondrial production rate does not change with increased mitophagy, and correspond to fraction of mitochondria stopped fs(ϕ = 0) = 0.53 in the absence of mitophagy.