Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations
Fig 5
Vesicle tethering and title of EAA1 coiled coil stalk relative to the bilayer normal.
The FYVE dimer is shown interacting with two PI(3)P molecules (orange) in a cell membrane (blue lines). Based on the analysis of our simulations this allows the coiled coil to tilt by up to 50° relative to the bilayer normal. Thus, the Rab5-binding domain (green) is able to search an area of ~0.09 μm2 for a contact to the target vesicle.