Biological impact of mutually exclusive exon switching
Fig 2
General statistics of our MXE dataset.
(A) Table showing the number of MXE events and MXE genes in each organism and a matrix with the percentage overlap of MXE gene orthologs between species. The percentage overlap refers to percentages of overlap between gene orthologs between species (e.g. 58% of human MXE genes have an ortholog in mouse). (B) Distributions of MXE exon sizes. MXE sizes were calculated by calculating the length of the MXE. The length of the longer isoforms were plotted. (C) Distribution of sequence identity between MXE pairs identifies one main distribution with its main peak between 50% and 70% sequence revealing likely conserved structure and function. A second much smaller peak around 90% indicates a subset of MXE events that are more recently evolved. Sequence identities were calculated by BLASTing two isoforms against each other. (D) Distribution of number of variable residues between MXE pairs demonstrates that the majority of MXEs have only a limited number of variable residues with almost all events <10 variable residues. Variable residues are amino acid residues that are variable in the alignment between MXE pairs.