Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation
Fig 9
Fibroblast numbers in simulated 2D granulomas (log10) comparing where (A) both fibroblasts to myofibroblast differentiation together with MMT or (B) MMT alone.
Number of myofibroblasts and activated fibroblasts are shown under A: fibroblasts and MMT involvement in fibrosis, B: MMT alone in fibrosis. Plots are shown on a log base 10 scale. C: Sensitivity analysis reveals key important parameters for increasing the number of myofibroblasts. PRCCs were calculated as described in Methods section and range between -1 and 1. Shown are only the significant PRCC values when the outcome variable is number of myofibroblasts for p < 0.05. Parameters are defined and explained in Table 2.