Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation
Fig 8
Snapshots of simulation show fibrosis occurring with both MMT and lung-resident fibroblast involvement.
A,B: None fibrotic, C,D: peripheral fibrosis, E,F: central fibrosis, G,H: fully fibrotic. Cells are represented by different colors as follows: resting macrophages are green, activated macrophages are blue, infected macrophages are orange, chronically infected macrophages are red, IFNγ producing T cells are pink, cytotoxic T cells are violet, regulatory T cells are cyan, fibroblasts are maroon, and myofibroblasts are gold.