Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation
Fig 5
Four distinct types of fibrosis phenotypes produced by the hypothesized MMT rules.
Plots show the macrophages that meet the STAT1+STAT3+Exposure- criteria for MMT (turquoise), or not (coral), at 50 days post-infection. The four fibrosis types are A: central fibrosis, B: peripheral fibrosis, C: fully fibrotic, and D: non-fibrotic. E: Average time between STAT1 phosphorylation signals in GranSim simulations. STAT1 signal comes before STAT3 signal in macrophages that are candidates for MMT.