Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
Fig 6
Exploring possible interactions nominates CaMKII as the key signaling node for missing crosstalks in ISO-specific network.
(A) Model predictions for crosstalks between CaMKII and network reactions through the “AND” gate. Each arrow represents a reaction that by adding an “AND” gate from CaMK to that reaction, we observed a significant improvement in model accuracy. (B) Model predictions for crosstalks between CaMKII and network nodes through the “OR” gate. The thicker red arrows illustrate reactions with higher positive effect on the validation percent in ISO-specific model.