Spatial considerations in the resolution of inflammation: Elucidating leukocyte interactions via an experimentally-calibrated agent-based model
Fig 8
A typical simulation of the inflammation model showing a chronic, globally inflamed outcome, for healthy choices of chemotactic parameters (kgrad = 80, σmem = 1) and all other model parameters as given in Table 1.
(A) Successive snapshots of the simulation in which high levels of pro-inflammatory mediators are shown in dark reds in the background; active/apoptotic neutrophils are shown in green/orange respectively and macrophages are shown in blue. (B–D) Global cell counts for active neutrophils, apoptotic neutrophils and macrophages respectively. (E,F) Maximal concentrations of mediators c and g across the domain. Solid lines represent the mean result over 100 simulations of the model; shaded areas represent plus/minus one standard deviation.