A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
Fig 5
Example of the dynamics of the tumor’s clonal composition.
A) Evolution of the eight clonal populations included in the model (one per row). Total tumor volume is shown as a light blue background. Times correspond to 8.5, 10 and 11.5 months. Parameters for this simulation are τrep = 179.1 h, τdeath = 292.5 h, τmut = 222.7 h, . Other parameters are as in Table 1. B) Tumor central slice showing in white high tumor cell density. C) Three-dimensional subtype composition of the tumor. D) Reconstruction of the phylogeny of the tumor. Each bifurcation represents a mutation. Bifurcations occurring first in each branch represent mutations appearing earlier in time.