Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet
Fig 3
Calibration of the model to clinical data from NSCLC patients.
A) Kaplan-Meier survival plot shows agreement between the virtual and clinical cohort. The black line shows the survival estimates for clinical data (solid line is an estimate, dotted lines define the 95% confidence interval). All other solid lines show Kaplan-Meier estimates for the virtual cohort (in total 100 cohorts with 1,000 patients each are shown). B) The plot shows agreement of the virtual cohort with a clinical one in terms of initial response. On the x-axis there is the initial response of patients by treatment effect: PD (progressive disease), SD (stable disease), PR (partial response) and CR (complete response) and on the y-axis there is proportion of patients in a cohort belonging to one of the four initial response class. C) The boxplot shows the relationship between the number of chemotherapy cycles (x-axis), and the time between the two consecutive chemotherapy cycles (y-axis).