Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape
Fig 10
Monotherapy results: Cell cycle phase composition.
Treatment responses for HAP (left) and IR (right) monotherapies for the ‘Small’ (top) and ‘Large’ (bottom) MCTS. The monotherapy is given at T0 = 0 hours. Graphs demonstrate cell-cycle specific composition (of viable, undamaged cells) over time. The slow/non-proliferative, inner cancer cells are labeled S/N-P. Solid lines show mean values for 10 in silico runs (standard deviations are negligible hence not shown).