Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape
Fig 8
The ‘Small’ (20 day old) MCTS and the ‘Large’ (30 day old) MCTS.
These two MCTSs are used to allow for comparisons in treatment responses between tumours with different oxygenation levels. Top: Simulation snapshots of the MCTSs at the time point T0 when treatments commence (A1: Small MCTS, B1: Large MCTS). Hypoxic cells (pO2≤ 10 mmHg) are green whilst normoxic cells are blue. Middle: Oxygen histograms at time T0, in which hypoxic cell counts are shown in green and normoxic cell counts are shown in blue (A2: Small MCTS, B2: Large MCTS). Bottom: Cell-cycle phase histograms at time T0 (A3: Small MCTS, B3: Large MCTS). The slow/non-proliferative, inner cancer cells are labeled S/N-P.