Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape
Fig 7
The oxygen enhancement ratio (OER) and the oxygen modification factor (OMF).
The OER and the OMF are incorporated in the mathematical model to quantify the influence of oxygen on radiotherapy responses. Cells are the least radiosensitive for low pO2 values. The OER and OMF curves have steep gradients between the oxygen values 0 and 10 mmHg, after which they respectively asymptote to the values 3 and 1 for higher oxygen values.