Assessing the performance of methods for copy number aberration detection from single-cell DNA sequencing data
Fig 5
Comparison of HMMcopy, Ginkgo and CopyNumber on Sample 102 in [43].
(a) Venn diagram of the breakpoints from Ginkgo, HMMcopy and CopyNumber. Breakpoints from two methods are counted as overlapping if they are within 400,000bp of each other. (b) Distribution of the copy number changes (under a parsimony analysis) per bin based on the copy number profiles obtained by HMMcopy for the seven samples. (c) Distribution of the copy number changes (under a parsimony analysis) per bin based on the copy number profiles obtained by Ginkgo for the seven samples. For (b) and (c), a maximum parsimony tree was inferred from the copy number profiles of the cells, and the minimum number of copy number changes per bin along all the branches of the tree was computed by parsimony analysis. The percentages of the bins with each number of copy number changes are plotted.