Personalized logical models to investigate cancer response to BRAF treatments in melanomas and colorectal cancers
Fig 5
Validation of personalized models with cell lines data.
(A) Pearson correlations between normalized Proliferation scores from personalized models and experimental sensitivities to BRAF inhibition by drug or CRISPR targeting; each row corresponds to a different personalization strategy; only the values for the significant correlations are displayed. (B) Scatter plots with non-overlapping points corresponding to correlations of panel A, with the three personalization strategies, focusing one one drug (PLX-4720) and one CRISPR dataset (Broad) only. (C) Enlargement of the scatter plot comparing model scores (personalized with mutations and RNA) and experimental sensitivity to CRISPR targeting of BRAF (left) with the corresponding table representing the omics profiles used for each cell line to explore the response mechanisms. This panel can be advantageously replaced by one of the interactive plots proposed in the provided code.