Mechanistic model of hormonal contraception
Fig 10
Simulation (solid blue line) of a temporary treatment of a low dose combined hormonal contraceptive. Dosing begin at day 84 (green dashed line) and ends at day 168 (red dashed line) at which point the dose decreases exponentially due to the half-life of the drug. A nearly instant contraceptive effect after dosing is observed and, once the drug is removed, return to ovulation occurs within 1-2 cycles.