A stochastic model for simulating ribosome kinetics in vivo
Fig 1
Diagram of the ribosome kinetic model.
(A) Illustration of the reaction network that is simulated in the model. Aminoacylation of tRNAs (dashed boxes) indicate an area where there is limited knowledge of the biochemical kinetics and additional experimental work is needed. (B) Overview of the implementation steps. Specific mRNA sequences, and the concentration of ribosomes, are used as input parameters. The program determines the quantities of elongation factors, etc. that are expected from the number of ribosomes based on experimental data [19]. Examples of output data are shown in the final column.