Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs
Table 1
Results of Novel Structure Prediction from Various GPCR Modeling Servers.
Blind predictions were carried out on C5aR1 (PDB ID 6C1R [39]), Y1R (PDB ID 5ZBQ [40]), PTAFR (PDB ID 5ZKQ [41]), and D2R (PDB ID 6CM4 [42]). 100 models were generated for each target with RosettaGPCR and the best scoring model was used for analysis. The RMSD of each model for the various servers were calculated for the TM region, ECL2, and the full model. The best performing model in each evaluation criteria is bolded. No data is available for GPCR-SSFE for D2R.