Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity
Fig 1
Schematic illustration of the Kv channel structure.
(A) A cartoon model of a subunit of the Kv channel showing the voltage-sensing domains (VSDs) (S1–S4) in yellow, the S4–S5 helical linker in green, the S5 helix in cyan, the P-helix in pink, and the S6 helix in blue. (B) Two opposite subunits of the pore domain of the Kv channel are represented by ribbons. The other two subunits have been omitted. The selectivity filter is shown in purple, and the water cavity is located below the water cavity. The hinge region in S6 helix is highlighted in red.