On measuring selection in cancer from subclonal mutation frequencies
Fig 1
Schematic representation of the stochastic model of tumor evolution.
a, Transformed cells (blue) divide with rate b, obtain an additional driver mutation with rate u, and die with rate d. Cells with the additional driver (red) divide with rate b1 and die with rate d1. The ratio of net growth rates of cells with and without the driver, c = (b1-d1)/(b-d) is greater than 1. b, Growth begins with a single parental cell. We are interested in the fraction of cells with the driver as a function of the total number of tumor cells M.