EternaBrain: Automated RNA design through move sets and strategies from an Internet-scale RNA videogame
Fig 4
Example EternaBrain-SAP solutions to Eterna100 puzzles.
(A) U solution highlights the fact that the EternaBrain CNN alone can solve puzzles with short stems. (B) Chicken Tracks solution: EternaBrain-SAP can solve puzzles with three stems intersecting in one internal loop. (C) Thunderbolt solution demonstrates that EternaBrain-SAP can solve large puzzles (400 nucleotides long) and solve loops and stems in combination. (D) Shortie 4 solution shows EternaBrain-SAP can solve puzzles with multiple short stems (2 nucleotides long). (E) Shortie 6 is quite similar to Shortie 4, but with the same motif (short stems) repeated. The other algorithms mentioned could not solve Shortie 6 because of the repeated motifs. (F) Hard Y—target structure (left) vs nature-mode (right) structure. EternaBrain-SAP could not solve Hard Y because it required use of a little-used strategy to solve a motif called a zigzag. Since the strategy is not often used by players, the EternaBrain CNN did not learn the strategy and the strategy was not included in the SAP. In each panel, the 5’ end of each puzzle is at the top left, with the puzzle drawn counter-clockwise from that point.