Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation
Fig 2
Final stem cell ratios for different growth rates and competition intensities.
The growth rate discrepancy, ρ, exerts a dominant effect upon whether the final population sizes favor healthy HSCs over mutant HSCs. If the mutant growth rate is higher, then it will be become the more dominant clone. However, the competition intensity between the healthy and mutant clone is also important in that it exacerbates the degree of asymmetry in the final composition. The black dot represents the ecological parameters of a healthy patient.