< Back to Article

Bayes-optimal estimation of overlap between populations of fixed size

Fig 6

Quantifying the decrease in uncertainty from increased sequencing.

Histograms show distributions of overlap estimates , computed using Eq (11), for various values of s which are indicated by color-matched dotted lines. While all estimates are distributed around the true values of s, increasing the number of colonies c from 48 (top) to 96 (middle) and to 144 (bottom) substantially decreases the error of estimates. For example the bottom plot shows that successfully sequencing c = 144 colonies from each parasite is guaranteed to produce estimates that are off by at most 5 (8.3%) in either direction of the true s.

doi: https://doi.org/10.1371/journal.pcbi.1006898.g006