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Bayes-optimal estimation of overlap between populations of fixed size

Fig 5

Reevaluation of published results.

In 2010, Albrecht et al. compared var repertoires from 5 populations using pairwise type sharing (see Refs. [18, 19, 27] for original data details). (left) Reproduction of analysis of [19], rescaled from [0, 1]→[0, 60]. (middle) Reanalysis using Bayesian repertoire overlap [Eq (7)]. For all boxplots, boxes span inner quartiles; center lines show medians; whiskers extend to 2.5 and 97.5 percentiles. (right) Histograms of Bayesian repertoire overlap distributions from Amele and Ariquemes clones (data identical to those in middle boxplots) colored by width of credible interval [Eq (8)], a measure of uncertainty. Differences in uncertainties are driven primarily by sampling rates: Amele samples average sequences per parasite while Ariquemes clones average .

doi: https://doi.org/10.1371/journal.pcbi.1006898.g005