A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons
Fig 3
Application with a K+ point source/sink pair in a 3-D box containing a standard ECS ion solution.
The source and sink were turned on at t = 0 s, and turned off at t = 1 s. The simulation was stopped at t = 2 s. (A) The total electrical potential ϕ at the end of the stimulus period (t = 1.0 s) in a plane intersecting the source and sink. (B) The volume conductor component of the electrical potential, ϕVC. (C) The diffusive component of the electrical potential ϕdiff. (D) The difference in the electric potential between points close to the point sources (blue line), also shown is the differences in the VC component of the potential (stapled yellow line). Δϕ is defined as Δϕ = ϕ(xleft) − ϕ(xright), where xleft and xright were points 5 μm away from the left and right, respectively (see Methods).