Evolutionary footprint of epistasis
Fig 6
UFE is preserved for different topologies at moderate epistasis' strengths.
Here we show the dependences on E for (a, b) correlation coefficients, (c) mutation frequency f, and (d) UFE on E for the five topologies in Fig 6. UFE is the estimate of E (Eq 6) from haplotype frequencies f01, f11 derived analytically for each topology (S1 Appendix). Parameters: f0 = 1/100. Thus UFE is exact for the isolated pairs, and overestimates E at large E for other topologies. Asymptotic expressions are given in S2 Table.