Evolutionary footprint of epistasis
Fig 3
Universal footprint of epistasis (UFE) predicts epistatic strength in a broad time range.
Value of E estimated from Eq 6 is plotted as a function of the actual value of E, where (a-d) correspond to different time points. Each dot represent a single Monte-Carlo run. Initial population is randomized with f = 0.5. Haplotype frequencies in Eq 6 are averaged over sites and pairs. Blue: known epistatic pairs. Red: the same number of randomly chosen pairs. Parameters: L = 300, s0 = 0.05, N = 500, μL = 0.5, ~1 interaction per site.