A computational model of epithelial solute and water transport along a human nephron
Fig 7
Impact of SGLT2 and NKCC2 inhibition on segmental delivery of Na+, K+, Cl−, and fluid, given per kidney.
Notations are analogous to Fig 2. SGLT2 inhibition lowers proximal convoluted tubular transport, whereas NKCC2 inhibition lowers thick ascending limb NaC; transport; both result in diuresis, natriuresis, and kaliuresis. Insets reproduce distal segment and urine values.