Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents
Fig 2
Basal reactivation of latently infected cells.
Time-evolution of protein copy numbers in latently infected cells obtained by stochastic simulations of the HIV-1 latency circuit (Methods) in the absence of intervention. Trajectories (lines) of each of the 2000 cells in one realization are shown. Those crossing the activation threshold of 500 copies (dashed line) are in purple and the rest in grey. The parameters employed for the simulations except kNFκB and kBasal are in Table 1. The values of the latter parameters and the resulting percentage activation, fon, are: (A) kNFκB = 9 × 10−5 molecules s-1 and kBasal = 6.14 × 10−3 s-1 yielding fon = 0.0395; (B) kNFκB = 10−4 molecules s-1 and kBasal = 6.14 × 10−3 s-1 yielding fon = 0.0475; (C) kNFκB = 9 × 10−5 molecules s-1 and kBasal = 7 × 10−3 s-1 yielding fon = 0.053; and (D) kNFκB = 10−4 molecules s-1 and kBasal = 7 × 10−3 s-1 yielding fon = 0.0656.