Dynamics and heterogeneity of brain damage in multiple sclerosis
Fig 7
Analysis of the distribution of the EDSS time series.
A) Distribution of the time intervals between the clinical relapses. The distribution is derived from the experimental data of the EDSS time series (orange), simulations from the ODE model of T cell cross-regulation [4] (light blue) and the results from the GEV distribution model (red line). B-C) Examples of the analysis of the EDSS time-series in patients with MS. Incremental changes in EDSS over time in the experimental series for (B) PPMS and (C) SPMS. The onset of ΔEDSS is marked with an asterisk.