Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Fig 4
Spatial distributions of FQs in simulated granulomas recapitulate MALDI-MS imaging in rabbit granulomas.
(A) Representative granulomas from rabbits (left) and simulations (right) showing different spatial distribution of GFX, MXF and LVX at 6 hours post dose. Simulations capture the qualitative differences between the three FQs. A quantitative comparison between our simulations and MALDI-MSI is not possible due to the semi-quantitative nature of the MALDI-MSI data. (B) Different distributions between GFX, MXF and LVX are consistent across all granulomas studied. Figures show average MALDI-MS abundance in rabbit granulomas (left) and concentrations in simulated granulomas (right) plotted as a function of distance from the edge of the granuloma (in μm). Solid lines show mean and dashed lines show standard deviation for 100 simulated granulomas and between 3 and 7 rabbit granulomas.