Dose-response relationships for environmentally mediated infectious disease transmission models
Fig 2
Cryptosporidium dose–response and dynamics.
a) Maximum-likelihood estimates of dose–response functions for Cryptosporidium. Data from [45]; sizes of data points correspond to sample size. Best-fit parameters are given in Table 3. b) Modeled fraction of infected people under different dose–response relationships. Model parameters are N = 1000, S0 = 999, I0 = 1, W0 = 0, σ = 1/7 [46], γ = 1/10 [46], κ = 8 and ρ = 0.15 so that κρ = 1.2 L [47], V = 4E8 L, α = 1E6/V (taken from a range [48]), μ = 0.069 (taken from a range [49]). Model results using the exact and approximate beta–Poisson functions lie nearly on top of each other, and those using the Hill-n and log-normal functions have no outbreak. c) Average pathogen dose over time for different dose–response relationships. Model parameters are as in Fig 2b. d) Low dose behavior of the dose–response functions given in Fig 2a. Confidence intervals are given in Fig 3.