Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism
Fig 4
Comparison of optimal regulatory programs.
(A) Optimal time-course of enzyme (in red) and intermediate (in blue) concentrations for σ = 1/30, uniform kinetics and no toxicity. (B) Optimal solution for the same parameters apart the low toxicity threshold β4 = 0.1 of intermediate X4. (C) Again the same parameters as in (A) apart the highly efficient third enzyme keff,3 = 10. Threshold are depicted as black lines and the arbitrary time horizon ranging from 0 to 30 is discarded for lucidity.