Genome-Wide Association between Transcription Factor Expression and Chromatin Accessibility Reveals Regulators of Chromatin Accessibility
Fig 4
Method comparison across all subfamilies.
Cumulative distribution of CAR ranks at the subfamily level for the 147 tested subfamilies using the three different modelling strategies: ‘standard linear regression’, ‘mixed model regression’ and ‘mixed model PC corrected’ (see legend of Fig 2 and Methods). We see strong enrichment of low ranks implying deviation from the null hypothesis. The linear mixed modelling increases enrichment of low CAR ranks.