Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons
Fig 5
The cells in the CaMKII blocker affected cluster were affected by the task learning through whole-cell twofold multiplication of the AMPA single-channel current.
A. The average single channel current of the cells in the CaMKII affected cluster from the trained group (T-reduced, n = 6) was approximately twice that of the average single channel current in the naive group (n = 13) and the non-affected cells in the trained group (T-not reduced, n = 11). B. The amplitude distribution curve of the cells in the more affected cluster could be reconstructed by multiplying all events in the naive group by a factor of two (T-reduced, n = 6; T-not reduced, n = 11; naïve, n = 13). C. The trained group deviated from the control group mainly by the sub-group of cells that exhibited a high single channel current. D. The cumulative frequency curve of the cell’s average distribution curve could not be fully explained by two-fold multiplication of the average event amplitude of a randomly selected 40% of the cells in the naive group.