Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons
Fig 2
The CaMKII blocker effect cannot be reversed by an additive model (left) or a 3-fold multiplicative model (right).
A, D: Amplitude distribution curve before and after CaMKII blocker (as in Fig 1C). The black curve in A was calculated assuming a model in which the amplitude of each event was increased by a random number ranging from zero to twice the difference between the average event amplitude before the blocker and after the blocker. The black curve in D was calculated assuming a model of multiplication by a factor of 3, where the fraction of events that were affected by the blocker was calculated for each cell and the calculated amplitude distribution curve was reconstructed accordingly. In both models the reverse calculation assuming these models did not yield an effective reversal of the blocker effect on the amplitudes distribution curve. B, E The effect of the blocker could not be reversed on a single cell basis, yielding a high average P value as was shown in the C, F.