Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data
Fig 3
Distance based modeling of the X chromosome.
(A) Histogram of sampled distance scale estimates γ. (B) Average distance matrix for the Gaussian error model with a flat plateau (upper diagonal) and for the lognormal model (lower diagonal). (C) Log evidence log Pr(D|I) for different data weighting parameters λ (the inverse temperature λ is varied from 10−4 to 1 in a replica exchange simulation to facilitate sampling of the posterior distribution).