A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity
Fig 4
Effects of the variation of the mtDNA content in mitochondrial function.
It is possible to observe a bifurcation point when the mtDNA content is equal to 0.73. For mtDNA contents higher than 0.73 the mitochondria are in a stable condition and recovers to baseline over time. For a mtDNA content lower than 0.73, the mitochondria are unstable and its function will perpetually deteriorate until collapse.