PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions
Fig 5
Workflow diagram of the PredictSNP2 webserver.
Upon submission of input variants, evaluation is performed with the integrated prediction tools. The raw scores produced by individual tools are transformed into overall decisions about deleteriousness and interpretable confidence scores according to the category of variants detected by ANNOVAR. In addition, links to relevant databases and on-line tools are provided to allow the user to better understand the genomic context and potential function of the corresponding genome region. Optionally, evaluation of missense mutations by PredictSNP1 can be requested.