Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations
Fig 8
Comparison of different Ig clusters.
The simulations are based on 50 Ig clusters (red) and 5 Ig clusters (black), respectively. The spontaneous unfolding rate constant (left panel) declines linearly but is perturbed by a Gaussian noise (SD = 0.2) in the case of 50 Ig clusters. The average force based on the Monte Carlo simulations of 50 titin strands (middle panel) as well as the probabilities of unfolding events as a function of half sarcomere length (right panel) are comparable between 50 Ig clusters (red) and 5 Ig clusters (black).