The Emotional Gatekeeper: A Computational Model of Attentional Selection and Suppression through the Pathway from the Amygdala to the Inhibitory Thalamic Reticular Nucleus
Fig 9
Inflexibility in the absense of both BA interneurons and plan cortical interneurons.
Axis and subplot labels are as in Fig 5. A, Plan map. The plan cortical interneurons are ‘lesioned’ in the simulation. B, C, Salience map. The BA interneurons are ‘lesioned’ in the simulation. D, E, F, Sensory map, including sensory cortex (D), sensory TRN sector (E) and sensory thalamus (F). G, Input to sensory thalamus (stimuli and distractors). H, Reinforcement signals and Conditioned Stimuli (CSs). When the interneurons in BA and plan cortex are 'lesioned' the simulation reveals inability of the network to reset the cortical plan signals (A) as well as the sensory attentional modulation from BA (B, C), leading to pathological inflexibility in both attention (D, F) and decision-making (A). During the second testing phase (to the right of the vertical dotted line) top-down bias is applied to the feed plan. (In this simulation M1 = 160 during the second testing phase).