Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications
Fig 8
Cell stiffness and cohesivity dictate invasion pattern from coherent motion.
Three different systems of cells are taken with different stiffness of cell-cell connections. Simulations for (a) a soft system with kc = 1 and kt = 1 (b) a medium stiff system with kc = 10 and kt = 1 (c) stiff system with kc = 10 and kt = 10. The number of cells in all the three cases are same and equal to 100. After reaching a steady state of rotation, confinement was removed at time, t = 50. The snapshots of cell migratory patterns at t = 55 and t = 60 are also shown. For the case of intermediate stiff system, cells migrate in clusters compared to softer system where cell invasion pattern is more scattered. At the highest stiffness, cells continue to rotate even after removal of boundary. The length scale for each set of figure is shown below them.