Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma
Fig 2
Decomposition of the TGP process.
Assumption Eq (1) implies that no other PA-I mutation occurs if type-I cells are already present in the system. Therefore, u can be set to zero when a single type-I cell emerged. This allows to decompose the process into two sub-processes. First, occurrence of unsuccessful mutants, which go extinct and, second, the occurrence of a successful mutant which leads to absorption in one of the PA states.