Unbiased Rare Event Sampling in Spatial Stochastic Systems Biology Models Using a Weighted Ensemble of Trajectories
Fig 9
Accelerated sampling of high P2 levels.
After 400 simulated seconds (∼1 week of wall time for one trajectory), we plot the histogram of the number of P2 molecules in the cell. The blue and green circles are the result of two independent weighted ensemble simulations. Note that some data points are missing, because not all weighted ensemble bins are necessarily populated by trajectory segments at all times.