Unbiased Rare Event Sampling in Spatial Stochastic Systems Biology Models Using a Weighted Ensemble of Trajectories

doi:10.1371/journal.pcbi.1004611

Unbiased Rare Event Sampling in Spatial Stochastic Systems Biology Models Using a Weighted Ensemble of Trajectories

Fig 6

Signal transduction network.

This rule-based model is translated into a system of chemical kinetics reactions by BioNetGen, and then simulated in a spatially realistic geometry by MCell. Figure adapted from [61]. Rate constants and further details are given in the SI.

doi: https://doi.org/10.1371/journal.pcbi.1004611.g006