SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis
Fig 6
Mouse Lung Epithelial Specific Transcriptional Regulatory Network.
(A) Rank importance of transcription factors (TFs) in the main connected component of epithelial specific transcriptional regulatory network (TRN). The sizes of the TF nodes are proportional to their average-ranked node importance. The main connected component of epithelial TRN is comprised of 348 nodes and 432 edges. The nodes in red are the TFs and the nodes in grey are differentially expressed genes (p-value<0.01) in epithelial cells and are not TFs. The edges were established using the first-order conditional dependence approach described in the Methods section with a cutoff at 0.05. (B) The Hopx local network (the first hop is shown). Hopx was the top ranked TF identified by driving force analysis (Table 1).