Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data
Fig 9
Adding lactate-induced cell death.
If above a certain concentration of lactate produced during glucogenesis, cell death occurs, population kinetics and spatial temporal profiles for conditions III ([G] = 25mM, [O] = 0.28mM), and II ([G] = 5mM, [O] = 0.28mM), as well as the growth phases of condition I ([G] = 1mM, [O] = 0.28mM) and condition IV ([G] = 25mM, [O] = 0.07mM) were correctly captured. The diffusion coefficient in the medium was assumed to be Dmed = 30 Dtum. The experimental growth curves are shown as boxplots (box: mean, lower & upper quartils, horizontal dashes: minimum & maximum), and the radial profiles as composition of mean (line) and standard deviation (error bars).